Cyclic neutropenia. Clinical case report

Karla Ivette Oliva Olvera, Violeta Magaña Barrios, Rodolfo Fragoso Ríos, Vicente Cuairán Ruidíaz


Cyclic neutropenia occurs due to the fluctuation of cellular
production levels of bone marrow stem cells. This is to say, they change during the cycle, and although numbers are recurrently low, function is normal. Cyclic neutropenia was fi rst described by Leale in 1910 with dominant autosomal character. It manifests approximately every 21 days, with range of 14 to 36 days, lasting 3-6 days per episode. During the time when there are few circulating neutrophils, the patient is susceptible to infections. The clinical picture of this process includes: susceptibility to infection, feverish conditions, oral ulcers, impetigo, increased lymph nodes, periodontitis and
stomatitis. It is important to stomatologically handle these patients; after inter-consultation with treating physician, prevent infection in a prophylactic scheme based on amoxicillin 50 mg/per kg weight or clindamycin 20 mg/per kg weight, review recent blood count results (maximum ten days before treatment). In emergency treatments pain and infection will be handled conservatively, with use of 0.12% chlorhexidine mouthwashes and Philadelphia solution when

Palabras clave

Cyclic neutropenia, odontology, mouth rehabilitation, prevention.

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