Osteocalcin expression in periodontal ligament when inducing orthodontic forces

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Maritere Villarreal Brito
Marco Antonio Álvarez Pérez
Francisco Javier Marichi Rodríguez

Resumen

Osteocalcin is a non-collagenous protein located in alveolar bone, root cementum and subpopulations of periodontal ligament cells. This protein plays an important role in the biomineralization process and in the extra-cellular matrix, regulating maturation of hydroxyapatite and osteoclast recruitment which participate in bone remodeling. Periodontal tissue new formation and remodeling is a vital part of the process during orthodontic movements. These movements, when force is exerted, cause tension in the cells, provoking adaptation which results in molecular and cellular responses which, in turn, can affect the extracellular matrix. Due to the aforementioned facts, the aim of the present research was to determine osteocalcin expression associated to periodontal remodeling when orthodontic forces are applied. Roth 0.022 ” fi xed brackets with a NiTi 0.016” archwire were applied to fi rst upper and lower bicuspids. This was applied to all teeth of both arches except to left lower and upper bicuspids. Bicuspids without brackets (t = 0) as well as with brackets to elicit orthodontic movements during 1, 3, 5, 7 and 9 days were extracted to assess osteocalcin expression in the extra-cellular matrix of the periodontal ligament. The RTPCR technique was followed to determine temporal and spatial expression of osteocalcin messengers. Osteocalcin expression in the experimental group was present in all test days, suggesting thus the fact that orthodontic movements elicit changes that are susceptible in osteocalcin protein messenger concentrations.

Detalles del artículo

Cómo citar
Villarreal Brito, M., Álvarez Pérez, M. A., & Marichi Rodríguez, F. J. (2019). Osteocalcin expression in periodontal ligament when inducing orthodontic forces. Revista Odontológica Mexicana Órgano Oficial De La Facultad De Odontología UNAM, 17(3). https://doi.org/10.22201/fo.1870199xp.2013.17.3 Ing.69746
Biografía del autor/a

Maritere Villarreal Brito

Coordinación de publicaciones.

Editora de la Revista Ódontológica Mexicana. Órgano Oficial de la Facultad de Odontología, UNAM.